Occasional hypersensitivity reactions have been observed, including serious skin rashes. Animal reproduction studies have not been conducted with atropine.
Most of the side effects of Atropine are directly related to its antimuscarinic action. Atropine has been found to cross the human placenta Kanto In another surveillance study of 50 pregnancies in the first trimester, Atropine use was not associated with an increased risk of malformations.
IV infusion off-label dose: Systemic doses slightly raise systolic and lower diastolic pressures and can produce significant postural hypotension.
It is used to dilate the pupils of the eyes and as an antispasmodic. Occasionally a large dose may cause atrioventricular A-V block and nodal rhythm. Pralidoxime 2-PAM can be effective against organophosphate poisoning because it can re-cleave this phosphorylation.
Anticholinergic Agents may enhance the ulcerogenic effect of Potassium Citrate.
Severity and frequency of adverse reactions are dose related. Monitor therapy Anticholinergic Agents: Anticholinergic Agents may enhance the anticholinergic effect of RimabotulinumtoxinB.
Consider therapy modification Ramosetron: Appropriate medications should not be withheld due to concerns of fetal teratogenicity Jeejeebhoy [AHA] Because of the hallucinogenic properties, some have used the drug recreationallythough this is potentially dangerous and often unpleasant.
In the eye it acts as a mydriatic and as a cycloplegic.
May diminish the anticholinergic effect of Anticholinergic Agents. Paralytic ileus may occur.As with other antimuscarinic agents, the major action of Atropine is a competitive or surmountable antagonism which can be overcome by increasing the concentration of acetylcholine at receptor sites of the effector organ (e.g., by using anticholinesterase agents which inhibit the enzymatic destruction of acetylcholine).
Atropine is a competitive antagonist of acetylcholine which binds to the muscarinic receptor in order to inhibit the parasympathetic nervous system. Atropine inhibits the muscarinic actions of acetylcholine on structures innervated by postganglionic cholinergic nerves, and on smooth muscles which respond to endogenous acetylcholine but are not so innervated.
As with other antimuscarinic agents, the major action of atropine is a competitive or surmountable antagonism which can be overcome by. Atropine reverses the muscarinic effects of cholinergic poisoning due to agents with acetylcholinesterase inhibitor activity by acting as a competitive antagonist of acetylcholine at muscarinic receptors.
atropine [at´ro-pēn] an anticholinergic alkaloid found in belladonna; it acts as a competitive antagonist of acetylcholine at muscarinic receptors, blocking stimulation of muscles and glands by parasympathetic and cholinergic sympathetic nerves; used as the sulfate salt as a smooth muscle relaxant, as an antiarrhythmic, as a preanesthetic to reduce.
It acts as a competitive antagonist of acetylcholine at muscarinic receptors, blocking stimulation of muscles and glands by parasympathetic and cholinergic sympathetic nerves; used as a smooth muscle relaxant, as a preanesthetic to reduce secretions, and as an antidote to organophosphate poisoning.Download